Glock Y, Puel J, Fauvel J M, Boccalon H, Vaislic C, Bounhoure J P, Puel P
Arch Mal Coeur Vaiss. 1981 Apr;74(4):399-407.
The results of twelve patients undergoing revascularisation procedures of infarcted myocardial territory alone were analysed quantitatively by planimetry in the right anterior oblique projection. Patients operated in the acute phase of myocardial infarction (2 cases) were distinguished from those with preinfarction syndromes (8 patients) and those with postinfarction angina (2 patients). Two posterior wall and ten anterior wall revascularisations were carried out by single bypass grafts (8) and double bypass grafts (2) with no operative deaths. The results were assessed 2 months to two years after operation (average: 6 months). Twelve of the fourteen bypass grafts were patent. Only one of the twelve operated patients, an anterior wall revascularisation, was considered a complete surgical failure: global left ventricular function and segmental wall movement progressively deteriorated with reduced contractility and velocity of fibre shortening. Improved contraction of both anterior and posterior walls was observed in the other 11 patients. The ejection fraction of the 9 patients with anterior wall revascularisation rose significantly from 47,1 +/- 10,5% to 56,3 +/- 3,5% and a similar rise was observed in systolic index (29,0 +/- 12,0 to 36,8 +/- 11,0 ml/syst./m2); the average akinetic end diastolic perimeter fell by 17%; segmental wall analysis of mean radial shortening and mean amplitude of excursion on the hemiaxes was improved, especially in the antero apical region: the corrected rates of mean excursion and average systolic work indices (33,2 +/- 15 to 41 +/- 13 gm/syst./m2) also increased. Surgical revascularisation of infarcted zones, made possible by new methods of cardioplagia and reliable circulatory assistance, may lead to improvement in global and segmental left ventricular function with minimal risk to the patient: this is thought to be due to an active mechanism and not to the passive process of scarring. Although a reserved attitude should be adopted in the acute phase of myocardial infarction, preinfarction syndromes and unstable postinfarction angina could well benefit from surgical management.
仅对12例接受梗死心肌区域血运重建手术的患者结果进行了定量分析,采用右前斜位投照的平面测量法。将心肌梗死急性期手术的患者(2例)与梗死前综合征患者(8例)及梗死后心绞痛患者(2例)区分开来。通过单支搭桥(8例)和双支搭桥(2例)对2例后壁和10例前壁进行了血运重建,无手术死亡病例。术后2个月至2年(平均6个月)对结果进行评估。14支搭桥血管中有12支通畅。12例手术患者中,仅1例前壁血运重建患者被视为手术完全失败:整体左心室功能和节段性室壁运动逐渐恶化,收缩性和纤维缩短速度降低。其他11例患者观察到前壁和后壁收缩均有改善。9例前壁血运重建患者的射血分数从47.1±10.5%显著升至56.3±3.5%,收缩指数也有类似升高(从29.0±12.0升至36.8±11.0 ml/收缩期/m²);平均无运动的舒张末期周长下降了17%;节段性室壁分析显示,平均径向缩短和半轴上的平均偏移幅度得到改善,尤其是在前壁心尖区域:平均偏移校正率和平均收缩功指数(从33.2±15升至41±13 gm/收缩期/m²)也增加。新的心脏停搏方法和可靠的循环辅助使梗死区域的手术血运重建成为可能,这可能会改善整体和节段性左心室功能,对患者的风险最小:这被认为是由于一种积极机制,而非瘢痕形成的被动过程。虽然在心肌梗死急性期应持保留态度,但梗死前综合征和不稳定的梗死后心绞痛可能会从手术治疗中获益。