合成促甲状腺激素释放激素及其类似物对家鸡（原鸡）生长激素分泌的影响。

Effect of synthetic thyrotrophin-releasing hormone and its analogues on growth hormone secretion in the domestic fowl (Gallus domesticus).

作者信息

Scanes C G, Harvey S, Morgan B A, Hayes M

出版信息

Acta Endocrinol (Copenh). 1981 Aug;97(4):448-53. doi: 10.1530/acta.0.0970448.

DOI:10.1530/acta.0.0970448

Abstract

Variations in plasma growth hormone (GH) concentrations following iv or sc administration of synthetic thyrotrophin-releasing hormone (TRH, Pyr-His-Pro-NH2) have been followed in immature and adult domestic fowl. TRH markedly stimulated GH secretion in newly hatched (1 and 2 day old) chicks and in 6-week-old cockerels but in adult male or female birds of two strains had very little effect, if any. Intravenous injection of 4 TRH analogues (Pyr-His-Mep-NH2, Pyr-Meh-Mep-NH2, Pyr-Meh-Mep-NH and Pyr-Meh-Pro-NH2) were also potent GH secretagogues in 6-week-old birds. The stimulatory effect of TRH or the TRH-analogues on GH secretion was not dose-related.

摘要

在家禽幼雏和成年禽中，已对静脉注射或皮下注射合成促甲状腺激素释放激素（TRH，焦谷氨酰-组氨酰-脯氨酰胺）后血浆生长激素（GH）浓度的变化进行了追踪研究。TRH显著刺激新孵化出的（1日龄和2日龄）雏鸡以及6周龄小公鸡的GH分泌，但对两个品系的成年雄禽或雌禽几乎没有影响（如果有影响的话也是微乎其微）。静脉注射4种TRH类似物（焦谷氨酰-组氨酰-甲基脯氨酰胺、焦谷氨酰-甲基组氨酰-甲基脯氨酰胺、焦谷氨酰-甲基组氨酰-脯氨酰胺和焦谷氨酰-甲基脯氨酰胺）对6周龄禽也是有效的GH促分泌剂。TRH或TRH类似物对GH分泌的刺激作用与剂量无关。