人单克隆（18种）和正常（8种）免疫球蛋白M的单糖组成：其糖链的结构模型建议
Monosaccharide composition of human monoclonal (18) and normal (8) IGM immunoglobulins: proposed structural models for their glycan chains.
作者信息
Cahour A, Ollier-Hartmann M P, Mihaesco C, Hartmann L
出版信息
Biomedicine. 1981 Sep;35(4):133-6.
The carbohydrate composition of 18 monoclonal IgM (Waldenström macroglobulinemia) was determined by gas-liquid chromatography. Two populations occurred with mean sugar contents of 7.3% (12 IgM and 10% (6 IgM). A value of 7.2% was obtained for 8 IgM prepared from 8 normal sera. On the basis of mean molar ratios established for each monosaccharide residue, structural models for oligosaccharide units are proposed. The number of complex glycan chains (N-acetyllactosaminic type) is higher in the 10% population, which would correspond to IgM with a mean sedimentation constant of 18.3So20, W. On the other hand, the 7.3% population has a lower content of "mature" chains and its sedimentation constant would be inferior: 17S)20, W.
通过气液色谱法测定了18种单克隆IgM（瓦尔登斯特伦巨球蛋白血症）的碳水化合物组成。出现了两个群体，平均糖含量分别为7.3%（12种IgM）和10%（6种IgM）。从8份正常血清制备的8种IgM的糖含量为7.2%。根据为每个单糖残基确定的平均摩尔比，提出了寡糖单元的结构模型。在平均沉降常数为18.3S₂₀,W的IgM群体中，复杂聚糖链（N-乙酰乳糖胺型）的数量较多。另一方面，7.3%的群体中“成熟”链的含量较低，其沉降常数也较低：17S₂₀,W。
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