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[泌尿生殖系统肿瘤患者体内的肽类激素促黄体生成素、促卵泡生成素、促甲状腺激素、催乳素、β-人绒毛膜促性腺激素和甲状旁腺激素]

[Peptide hormones LH, FSH, TSH, prolactin, beta-HCG and PTH in patients with urogenital tumors].

作者信息

Dunzendorfer U, Drahovsky D, Schmidt-Gayk H

出版信息

Onkologie. 1981 Aug;4(4):188-92. doi: 10.1159/000214908.

Abstract

Serum levels of the peptide hormones, LH, FSH, TSH, prolactin, beta-HCG and PTH are observed to significantly modulate in patients with urogenital tumors, beta-HCG appears elevated in patients with chorioncarcinoma, teratoma and embryonal carcinoma and is shown to increase serum prolactin. TSH and prolactin are measured in pathological range in patients with renal carcinomas. Following nephrectomy serum TSH persists in high levels only in patients with advanced diseases, while PTH is more frequently suppressed in these patients. Serum LH and prolactin show a more distinct change of values in infiltrating bladder cancer, when compared to that of noninvasive bladder carcinomas. Prostate benign hyperplasia and cancer demonstrate similar ranges for peptide hormones, that will be changed by estrogen treatment in its LH, TSH and prolactin pattern. Serum levels of peptide hormones are affected by a complex system of ectopic hormone production, synthesis of peptide analogues, metabolic changes due to age and treatment.

摘要

观察到泌尿生殖系统肿瘤患者血清中促黄体生成素(LH)、促卵泡生成素(FSH)、促甲状腺激素(TSH)、催乳素、β-人绒毛膜促性腺激素(β-HCG)和甲状旁腺激素(PTH)等肽类激素水平有显著变化。β-HCG在绒毛膜癌、畸胎瘤和胚胎癌患者中升高,并显示会使血清催乳素增加。肾癌患者的TSH和催乳素水平在病理范围内。肾切除术后,只有晚期疾病患者的血清TSH持续处于高水平,而这些患者的PTH更常受到抑制。与非浸润性膀胱癌相比,浸润性膀胱癌患者血清LH和催乳素的数值变化更为明显。前列腺良性增生和癌症患者的肽类激素水平范围相似,雌激素治疗会改变其LH、TSH和催乳素模式。血清肽类激素水平受异位激素产生、肽类似物合成、年龄和治疗引起的代谢变化等复杂系统的影响。

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