Popiel I, Erasmus D A
Trans R Soc Trop Med Hyg. 1981;75(2):287-91. doi: 10.1016/0035-9203(81)90336-9.
It has been found that treatment of mice infected with Schistosoma mansoni with thiosinamine for five days had a significant effect on the formation of normal egg-shells within the ootype of female worms. The protein material, not organized into complete egg-shells, was nevertheless tanned and the surface of these amorphous masses was formed into microspines. Normal egg-shell formation was restored following drug withdrawal. The process of egg-shell formation consists of the integration of the physical moulding of egg-shell precursors derived from the vitelline cells, associated with the chemical process of protein tanning. It is suggested that thiosinamine treatment in vivo results in disruption of egg-shell formation by causing a breakdown in the moulding process and not by the inhibition of protein tanning involving the enzyme polyphenoloxidase. Treatment of worms with the drug under in vitro conditions resulted in a more enhanced effect of egg-shell formation.
已发现，用硫代辛胺对感染曼氏血吸虫的小鼠进行为期五天的治疗，对雌虫卵模内正常卵壳的形成有显著影响。虽未组织成完整卵壳的蛋白质物质经过了鞣制，且这些无定形团块的表面形成了微刺。停药后恢复了正常的卵壳形成。卵壳形成过程包括来自卵黄细胞的卵壳前体物理成型的整合，以及蛋白质鞣制的化学过程。有人认为，硫代辛胺在体内的治疗导致卵壳形成中断是因为造成成型过程的破坏，而非涉及多酚氧化酶的蛋白质鞣制受到抑制。在体外条件下用该药物处理蠕虫，对卵壳形成的影响更大。
