Morray J P, Fox W W, Kettrick R G, Downes J J
Crit Care Med. 1981 Dec;9(12):815-8. doi: 10.1097/00003246-198112000-00001.
The hospital records of 7 patients with severe bronchopulmonary dysplasia (BPD) were reviewed. All patients were ventilator dependent for prolonged periods (mean duration intermittent mandatory ventilation (IMV) 14.3 +/- 3.5 months) but eventually were successfully weaned from mechanical ventilation and sent home. The early phase of the disease was characterized by excessive CO2 retention, tachypnea, and inability to tolerate reductions in IMV. A turning point was reached halfway through the course of mechanical ventilation (7.3 +/- 1.4 months) which was identified by a persistent and significant reduction in PaCO2 and spontaneous respiratory rate. Thereafter, gradual reductions in IMV were generally well tolerated. Average monthly weight gain was less prior to the turning point it was subsequently.
回顾了7例重度支气管肺发育不良（BPD）患者的医院记录。所有患者长期依赖呼吸机（平均间歇强制通气（IMV）持续时间为14.3±3.5个月），但最终成功脱机并出院。疾病早期的特征为二氧化碳潴留过多、呼吸急促以及无法耐受IMV降低。在机械通气过程中（7.3±1.4个月）达到了一个转折点，其标志为PaCO2和自主呼吸频率持续且显著降低。此后，IMV的逐渐降低通常耐受性良好。转折点之前的平均每月体重增加低于其后的水平。
