在香烟烟雾通气过程中，离体大鼠肺中花生四烯酸的代谢没有变化。

The metabolism of arachidonic acid in isolated rat lungs is not changed during cigarette smoke ventilation.

作者信息

Männistö J, Hartiala J, Nienstedt W, Uotila P

出版信息

Prostaglandins Leukot Med. 1982 Jan;8(1):23-6. doi: 10.1016/0262-1746(82)90122-6.

Abstract

Cigarette smoke ventilation of isolated perfused rat lungs partially inhibited the pulmonary vascular pressor response to arachidonic acid. The amounts of metabolites of exogenous arachidonic acid in the perfusion effluent remained unchanged during smoke ventilation. The antiaggregatory effect of the effluent during pulmonary infusion of AA was not decreased by smoke ventilation. The cause of the previously reported increased platelet aggregation after smoking remains unclear.

摘要

对离体灌注大鼠肺进行香烟烟雾通气可部分抑制肺血管对花生四烯酸的升压反应。在烟雾通气期间，灌注流出液中外源性花生四烯酸的代谢产物量保持不变。在肺灌注花生四烯酸期间，流出液的抗聚集作用并未因烟雾通气而降低。先前报道的吸烟后血小板聚集增加的原因仍不清楚。