Raviola C A, Nichter L, Baker J D, Busuttil R W, Barker W F, Machleder H I, Moore W S
Am J Surg. 1982 Jul;144(1):115-23. doi: 10.1016/0002-9610(82)90611-0.
The consequences of failure in 235 femoropopliteal and femorotibial operations are reviewed and compared with the benefits of success so that an accurate perspective of risk-benefit analysis can be achieved. In 72 operations performed for claudication, 10 grafts thrombosed early. The cost included nine reoperations to achieve eight patent grafts and a 12 day average increase in hospital stay. There were no deaths. The benefit obtained was 70 of 72 (97 percent) asymptomatic limbs. In 163 grafts placed for limb salvage, there were 58 initial thromboses. Reoperation in 28 produced an additional 14 patent grafts. The cost of thrombosis was an increase in mortality from 5.6 to 10.7 percent, a 12 day average increase in hospital stay, and raising of preoperative predicted amputation level from below to above the knee in 11 patients with thrombosed grafts whose distal anastomoses were below the knee. This contrasted with a 73 percent limb salvage rate in 104 patients whose preoperative predicted amputation level was below the knee, and a 54 percent limb salvage and a 12 percent lowering of amputation level in 39 patients whose preoperative amputation level was above the knee. Of patients with patent grafts, 89 percent achieved limb salvage. We conclude that the benefits of success in attempted vascular reconstruction for threatened limb loss far outweigh the risks of failure and that the combined results were far superior to the expected outcome in comparable patients undergoing primary amputation.
回顾了235例股腘动脉和股胫动脉手术失败的后果,并与成功的益处进行了比较,以便能够准确地进行风险效益分析。在为间歇性跛行进行的72例手术中,有10条移植物早期血栓形成。代价包括9次再次手术以获得8条通畅的移植物以及平均住院时间增加12天。无死亡病例。获得的益处是72例中有70例(97%)肢体无症状。在为挽救肢体而置入的163条移植物中,有58条最初发生血栓形成。28例再次手术又产生了14条通畅的移植物。血栓形成的代价是死亡率从5.6%升至10.7%,平均住院时间增加12天,并且在11例移植物血栓形成且远端吻合口在膝关节以下的患者中,术前预计的截肢平面从膝关节以下升至膝关节以上。这与104例术前预计截肢平面在膝关节以下的患者73%的肢体挽救率形成对比,以及39例术前截肢平面在膝关节以上的患者54%的肢体挽救率和截肢平面降低12%形成对比。在移植物通畅的患者中,89%实现了肢体挽救。我们得出结论,对于濒临肢体丧失的患者,尝试进行血管重建成功的益处远远超过失败的风险,并且综合结果远远优于接受一期截肢的类似患者的预期结果。