Courot M
Reprod Nutr Dev (1980). 1980;20(2):587-91.
ABP is a protein found in the testicular cytosol or secreted by Sertoli cells in the rete testis fluid. It has a high affinity for androgers and binds specifically 5 alpha-DHT and testosterone (but to a lesser extent). The binding capacity is saturable. ABP is measured by steady state polyacrylamide gel electrophoresis or by separation on dextran coated charcoal. ABP moves from testis to epididymis where its binding activity is totally or partially destroyed from caput to cauda epididymis. In some species (ram, bull, billy goat) but not in others (human, boar, stallion) ABP is present in the seminal plasma of the ejaculate. In some species like the rat, ABP is also secreted in the testicular blood stream by Sertoli cells through the basement membrane of the seminiferous tubules. ABP varies with age and with season. Its production is under separate endocrine control of FSH and testosterone and its transport from testis to epididymis is specifically controlled by FSH. Through its binding activity, ABP may play a role in spermatogenesis and epididymal sperm maturation by enhancing the local concentration of androgens around the germinal cells and the male gametes. However ABP is not present in some species, like the pig, although their spermatogenesis and epididymal sperm maturation are normal.
雄激素结合蛋白（ABP）是一种存在于睾丸胞质溶胶中的蛋白质，或由睾丸网液中的支持细胞分泌。它对雄激素具有高亲和力，能特异性结合5α-双氢睾酮和睾酮（但亲和力稍低）。其结合能力是可饱和的。ABP可通过稳态聚丙烯酰胺凝胶电泳或用葡聚糖包被活性炭分离来测定。ABP从睾丸转运至附睾，在附睾中其结合活性从附睾头到附睾尾会全部或部分被破坏。在某些物种（公羊、公牛、雄山羊）中，ABP存在于射精的精浆中，但在其他物种（人类、公猪、种马）中则不存在。在一些物种如大鼠中，支持细胞还通过生精小管的基底膜将ABP分泌到睾丸血流中。ABP会随年龄和季节变化。其产生受促卵泡激素（FSH）和睾酮的独立内分泌控制，而其从睾丸到附睾的转运则由FSH特异性控制。通过其结合活性，ABP可能通过提高生精细胞和雄配子周围雄激素的局部浓度，在精子发生和附睾精子成熟过程中发挥作用。然而，在某些物种如猪中，尽管其精子发生和附睾精子成熟正常，但不存在ABP。
