Kojiro M, Kage M, Abe H, Imamura M, Shiraishi K, Mizoguchi M
Cancer. 1983 Feb 15;51(4):712-5. doi: 10.1002/1097-0142(19830215)51:4<712::aid-cncr2820510426>3.0.co;2-6.
A 22-year-old woman presented with splenomegaly and pancytopenia of over two years' duration. A splenectomy was performed because of a suspicion of Gaucher's disease. At the time of operation a left ovarian tumor was found and was removed. A diagnosis of Gaucher's disease was made on the basis of massive infiltration of histiocytes with typical cytoplasmic striations in the spleen, liver, and bone marrow. The ovarian tumor was characterized by a monotonous, diffuse proliferation of large, rounded cells and was diagnosed as dysgerminoma. The association of Gaucher's disease and malignant tumors is rare, only several cases have been reported in the English literature. An additional feature of this case was the appearance of histiocytes showing the characteristic cytoplasmic striations of Gaucher's cells in the stroma of the tumor.
一名22岁女性，出现脾肿大和全血细胞减少两年多。因怀疑患有戈谢病而行脾切除术。手术时发现左侧卵巢肿瘤并将其切除。根据脾脏、肝脏和骨髓中组织细胞大量浸润并伴有典型的细胞质条纹，诊断为戈谢病。卵巢肿瘤的特征是大的圆形细胞呈单调、弥漫性增殖，诊断为无性细胞瘤。戈谢病与恶性肿瘤的关联罕见，英文文献中仅报道过几例。该病例的另一个特点是在肿瘤间质中出现了具有戈谢细胞特征性细胞质条纹的组织细胞。
