Time-dependent induction of hepatic drug metabolism in rats by cotinine.
作者信息
Kyerematen G A, Passananti G T, Greene F E, Vesell E S
出版信息
Life Sci. 1983 Jan 31;32(5):551-6. doi: 10.1016/0024-3205(83)90151-0.
PMID:6823211
Abstract
Cotinine, administered twice a day for 2 days in a dose of 20 or 40 mg/kg i.p., induced rat hepatic drug metabolism between 22% to 62%. Induction decreased to 26-37% after 4 days of cotinine (40 mg/kg bid). No significant induction was observed after 8 days of this dose of cotinine. Explanations are offered for decreasing induction by cotinine with time.
摘要
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