鸡胚培养小脑神经元中钙电流和钠电流诱导产生的复合峰电位

Combined spikes induced by Ca and Na currents in cultured cerebellar neurons from the chick embryo.

作者信息

Mori-Okamoto J, Ashida H, Maru E, Tatsuno J

出版信息

Brain Res. 1983 Jan 10;258(2):318-22. doi: 10.1016/0006-8993(83)91158-7.

Abstract

Evoked spikes in explanted cerebellar neurons cultured for 17-25 days, presumably including Purkinje cells, were not completely blocked by 10(-5) g/ml TTX. The TTX-resistant components of the spike were suppressed by Co2+ or Mn2+. It is suggested that combined Ca and Na components are involved in spike generation mechanisms in cultured neurons from the chick cerebellum and that they may be related to the maturation process of excitable membranes of cell soma.

摘要

培养17 - 25天的离体小脑神经元（可能包括浦肯野细胞）所诱发的峰电位，并未被10⁻⁵克/毫升的河豚毒素完全阻断。峰电位的河豚毒素抗性成分被钴离子或锰离子抑制。这表明钙和钠成分共同参与了鸡小脑培养神经元的峰电位产生机制，并且它们可能与细胞体可兴奋膜的成熟过程有关。