Stringfellow D A, Brown R R, Hanson L E, Schnurrenberger P R, Johnson J
J Am Vet Med Assoc. 1983 Jan 15;182(2):165-7.
A commercially available leptospiral bacterin containing 5 serovars (canicola, grippotyphosa, hardjo, icterohemorrhagiae, pomona) was used per label directions to vaccinate 45 steers and bulls. In animals in which the prevaccination sera were negative for microscopic agglutinating antibody, the increase and decrease of titers were similar among all serovars. A serologic response was stimulated by a single dose and enhanced by the 2nd dose. Most titers peaked at 2 weeks and then fell rapidly by 15 weeks after the 2nd dose. Thirty-four animals with prevaccinal titers to serovar hardjo responded with high microscopic agglutinating titers for a sustained period. Of these cattle, 31 still had titers between 200 and 400 by 29 weeks after the 2nd dose. These results were interpreted as representing an anamnestic response initiated by the bacterin to a sensitization that had followed natural exposure.
按照标签说明，使用一种市售的包含5种血清型（犬型、爪哇型、哈焦型、出血性黄疸型、波摩那型）的钩端螺旋体菌苗对45头阉牛和公牛进行接种。在接种前血清显微镜凝集抗体呈阴性的动物中，所有血清型的滴度升降情况相似。单剂量激发了血清学反应，第二剂增强了该反应。大多数滴度在第二剂接种后2周达到峰值，然后在15周时迅速下降。34头对哈焦血清型接种前有滴度的动物产生了高显微镜凝集滴度，并持续了一段时间。在这些牛中，到第二剂接种后29周时，31头牛的滴度仍在200至400之间。这些结果被解释为代表菌苗引发的针对自然暴露后致敏的回忆反应。
