Yoshimine T, Yanagihara T
J Neurosurg. 1983 Mar;58(3):362-7. doi: 10.3171/jns.1983.58.3.0362.
The authors have created an experimental model of regional cerebral ischemia in gerbils that is reproducible and has a low mortality rate. In gerbils, either the posterior communicating artery (PCoA) or the middle cerebral artery (MCA) was occluded, and the distribution of cerebral ischemia from each surgical procedure was compared with that produced by occlusion of the common carotid artery (CCA). In contrast to the widespread cortical and subcortical infarctions seen after occlusion of the CCA, occlusion of the PCoA caused infarction that was restricted to the hippocampus, the piriform cortex, and the posterior part of the thalamus, and occlusion of the MCA resulted in infarction that was restricted to the central part of the cerebral hemisphere and the caudate nucleus and putamen. Intracranial occlusion of the PCoA or MCA in the gerbil resulted in lesions that were reproducible with low mortality rates over a long-term period. Occlusion of the PCoA, MCA, or CCA also produces a model that is suitable for investigation of the postischemic period. A combination of these three experimental models is useful for investigation of regional vulnerability and for the study of regional metabolic differences in cerebral ischemia.
作者创建了一种沙鼠局部脑缺血的实验模型，该模型具有可重复性且死亡率低。在沙鼠中，分别阻断后交通动脉（PCoA）或大脑中动脉（MCA），并将每种手术操作引起的脑缺血分布与颈总动脉（CCA）阻断所产生的脑缺血分布进行比较。与CCA阻断后出现的广泛皮质和皮质下梗死不同，PCoA阻断导致梗死局限于海马、梨状皮质和丘脑后部，而MCA阻断导致梗死局限于大脑半球中部以及尾状核和壳核。沙鼠颅内PCoA或MCA阻断导致的病变在长期内具有可重复性且死亡率低。PCoA、MCA或CCA阻断还产生了一个适合研究缺血后时期的模型。这三种实验模型的组合对于研究局部易损性和脑缺血区域代谢差异很有用。
