氨基-β-咔啉对姐妹染色单体交换诱导的作用。

Actions of amino-beta-carbolines on induction of sister-chromatid exchanges.

作者信息

Tohda H, Tada M, Sugawara R, Oikawa A

出版信息

Mutat Res. 1983 Feb;116(2):137-47. doi: 10.1016/0165-1218(83)90104-0.

Abstract

Synthetic 3-aminoharman and 3-aminonorharman (amino-beta-carbolines) caused slight but definite induction of sister-chromatid exchanges (SCEs) in human lymphoblastoid cells NL3 and Chinese hamster cells CHO-K1. These amino-beta-carbolines are ranked between 2-amino-alpha-carboline and 2-amino-6-methyl-9a-aza-delta-carboline (Glu-P-2) and much lower than 3-amino-gamma-carbolines (Trp-P-1 and 2) in inductive activity. 1-Amino-beta-carboline, harman and norharman had very weak, if any, SCE-inducer activity. Norharman had a synergistic effect with aromatic amines such as Trp-P-2 and aniline on SCE induction, while 3-aminoharman suppressed SCE induction by more potent inducers such as Trp-P-2 and benzo[a]pyrene.

摘要

合成的3-氨基哈尔满和3-氨基去氢哈尔满（氨基-β-咔啉）在人淋巴母细胞系NL3和中国仓鼠细胞CHO-K1中引起了轻微但确切的姐妹染色单体交换（SCE）诱导。这些氨基-β-咔啉的诱导活性介于2-氨基-α-咔啉和2-氨基-6-甲基-9a-氮杂-δ-咔啉（Glu-P-2）之间，远低于3-氨基-γ-咔啉（Trp-P-1和2）。1-氨基-β-咔啉、哈尔满和去氢哈尔满即使有SCE诱导活性也非常弱。去氢哈尔满与色氨酸-P-2和苯胺等芳香胺在SCE诱导上具有协同作用，而3-氨基哈尔满则抑制色氨酸-P-2和苯并[a]芘等更强效诱导剂的SCE诱导作用。