Ogievetskaia M M
Mol Biol (Mosk). 1978 Jul-Aug;12(4):829-35.
The capacity of proteins to induce the synthesis of specific immunoglobulins was shown to be correlated with their evolution rate. This correlation can be understood in terms of the clonal-selectional theory. The characteristic correlation parameter is the number of differences in the amino acid sequences between the immunogenic protein and the homological protein of the immunized animal. The above correlation was traced most clearly for the evolutionary conservative proteins.
蛋白质诱导特定免疫球蛋白合成的能力被证明与其进化速率相关。这种相关性可以根据克隆选择理论来理解。特征相关参数是免疫原性蛋白质与免疫动物的同源蛋白质之间氨基酸序列的差异数量。对于进化保守的蛋白质,上述相关性最为明显。