4-氨基丁醛作为一种可在体内转化为γ-氨基丁酸的物质。

4-Aminobutyraldehyde as a substance convertible in vivo to GABA.

作者信息

Sugahara M, Asakura T, Kurioka S, Matsuda M

出版信息

J Neurochem. 1983 Jan;40(1):294-6. doi: 10.1111/j.1471-4159.1983.tb12686.x.

DOI:10.1111/j.1471-4159.1983.tb12686.x

Abstract

[2,3-3H]4-Aminobutyraldehyde ([3H]ABAL) was injected subcutaneously into mice, which were sacrificed at various intervals following injection. [3H] gamma-Aminobutyric acid ([3H]GABA) synthesized in vivo from [3H]ABAL was extracted from the brains, separated, and quantitated. The results showed that in the brain, injected [3HABAL was rapidly transformed into [3H]GABA. [3H]ABAL may penetrate the blood--brain barrier into the central nervous system and then be oxidized to [3H]GABA.

摘要

将[2,3-³H]4-氨基丁醛（[³H]ABAL）皮下注射到小鼠体内，在注射后的不同时间间隔处死小鼠。从大脑中提取、分离并定量由[³H]ABAL在体内合成的[³H]γ-氨基丁酸（[³H]GABA）。结果表明，在大脑中，注射的[³H]ABAL迅速转化为[³H]GABA。[³H]ABAL可能穿透血脑屏障进入中枢神经系统，然后被氧化为[³H]GABA。

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引用本文的文献

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Purification and characterization of a rat brain aldehyde dehydrogenase able to metabolize gamma-aminobutyraldehyde to gamma-aminobutyric acid.一种能够将γ-氨基丁醛代谢为γ-氨基丁酸的大鼠脑醛脱氢酶的纯化与特性分析

Biochem J. 1990 Jul 1;269(1):25-9. doi: 10.1042/bj2690025.

2

Developmental change of an enzyme activity oxidizing gamma-aminobutyraldehyde to gamma-aminobutyric acid in the chick embryonic brain.鸡胚脑中将γ-氨基丁醛氧化为γ-氨基丁酸的酶活性的发育变化。

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