Agerskov K, Henriksen O
Cardiovasc Res. 1983 Jan;17(1):22-5. doi: 10.1093/cvr/17.1.22.
Invasive blood pressure measurements were performed in the common femoral- and popliteal artery of six limbs with occlusion of the superficial femoral artery during upright exercise (heel raising) and intraarterial alpha-receptor blockade. Femoral blood flow was obtained by an indicator dilution method injecting 131 RISA into the femoral artery and sampling from the popliteal artery. Exercise increased femoral blood flow from an average of 184 (SE +/- 27) cm3 . min-1 at rest to 531 (SE +/- 61) cm3 . min-1 during a 40 degrees head up tilt. Intraarterially induced alpha-receptor blockade caused a further increase in blood flow to 685 (SE +/- 86) cm3 . min-1 during exercise. Changes in collateral arterial resistance was calculated relative to the supine resting value. During exercise a decrease of 24% (SE +/- 13) was observed. After alpha-receptor blockade and exercise collateral resistance decreased by 46% (SE +/- 12). The results indicate that the passive head-up tilt induced a constriction of the collateral arteries which is abolished by heel raising exercise (ie standing on tip toe). It seems, however, that during these circumstances there still remains some alpha-receptor mediated constriction of the collateral arteries which is blocked by intraarterially injected alpha-receptor blocking agents.
在六只肢体的股总动脉和腘动脉进行有创血压测量，这些肢体的股浅动脉在直立运动（踮起脚跟）和动脉内α受体阻断期间发生闭塞。通过向股动脉注射131碘化玫瑰红并从腘动脉采样的指示剂稀释法获得股血流量。运动使股血流量从静息时平均184（标准误±27）cm³·min⁻¹增加到40度头高位倾斜时的531（标准误±61）cm³·min⁻¹。动脉内诱导的α受体阻断使运动期间血流量进一步增加到685（标准误±86）cm³·min⁻¹。相对于仰卧位静息值计算侧支动脉阻力的变化。运动期间观察到下降24%（标准误±13）。α受体阻断和运动后，侧支阻力下降46%（标准误±12）。结果表明，被动头高位倾斜诱导侧支动脉收缩，而踮起脚跟运动（即踮脚尖站立）可消除这种收缩。然而，似乎在这些情况下，侧支动脉仍存在一些α受体介导的收缩，而动脉内注射α受体阻断剂可阻断这种收缩。
