Hanaoka T
Nihon Seikeigeka Gakkai Zasshi. 1983 Feb;57(2):151-66.
The effects of pulsed micro-electrical currents on internal remodeling in the cortex of long tubular bone were evaluated by the following three experiments. 1. Electrodes were inserted in both femora of 14 adult mongrel dogs, 15 mm apart, and pulsed micro-electrical current was applied in the right femoral cortex for 4 weeks, but not in the left femur, which was left as a control. Dogs were divided into 4 groups; in each of these groups current with 1Hz-10 microA, 0.1 Hz-10 microA, 50 Hz-10 microA and 1Hz-20 microA was applied. The effects were evaluated by histometric parameters, i.e. number of resorption cavities (Ar), osteons with osteoid seam (osAf), mineralization rate of osteoid seam (Mo), and perimeter of osteoid seam (Sf). Number of Ar and osAf increased. Bone formation rate (Vf) which is the product of osAf, Mo and Sf increased, especially in the group in which current with 1Hz-10 microA was applied. The main reason for increase of Vf was considered due to that the activation frequency in internal remodeling increased by electrical stimulation. 2. A metal plate was placed on the right humerus, not on the left humerus, both femora of 5 dogs, and electrical current of 1Hz-10 microA was applied in the right femur for either 12 or 16 weeks. Decrease of internal remodeling tended to take place in the mid-portion of the plated area of femur, whereas Vf increased by pulsed micro-electrical currents. Decrease of internal remodeling thus caused by placing a plate and screws increased by pulsed micro-electrical current. 3. Number of osteons in the newly formed bone in the osteotomized gap and in the cortex adjacent to the gap of femora of 7 dogs, which were plated for either 4 or 6 weeks, was measured in longitudinal sections labelled by tetracycline. The number of osteons increased more in the right femur in which current of 1Hz-10 microA was applied than in the left femur. Based on the results above described, it was concluded that bone healing was enhanced by pulsed micro-electrical currents.
通过以下三个实验评估了脉冲微电流对长管状骨皮质内部重塑的影响。1. 将电极插入14只成年杂种狗的双侧股骨，相距15毫米，对右侧股骨皮质施加脉冲微电流4周，左侧股骨不施加，作为对照。将狗分为4组；在每组中分别施加1Hz - 10微安、0.1Hz - 10微安、50Hz - 10微安和1Hz - 20微安的电流。通过组织计量学参数进行评估，即吸收腔数量（Ar）、带有类骨质缝的骨单位数量（osAf）、类骨质缝的矿化率（Mo）和类骨质缝周长（Sf）。Ar和osAf数量增加。作为osAf、Mo和Sf乘积的骨形成率（Vf）增加，尤其是在施加1Hz - 10微安电流的组中。Vf增加的主要原因被认为是由于电刺激使内部重塑中的激活频率增加。2. 在5只狗的右侧肱骨而非左侧肱骨以及双侧股骨上放置金属板，对右侧股骨施加1Hz - 10微安的电流，持续12周或16周。股骨钢板区域中部的内部重塑趋于减少，而脉冲微电流使Vf增加。放置钢板和螺钉导致的内部重塑减少因脉冲微电流而加剧。3. 在7只狗的股骨截骨间隙及间隙相邻皮质的新形成骨中，测量经四环素标记的纵切片中的骨单位数量，这些狗被钢板固定4周或6周。施加1Hz - 10微安电流的右侧股骨中的骨单位数量比左侧股骨增加得更多。基于上述结果，得出结论：脉冲微电流可促进骨愈合。
