Głuskowski J, Jedrzejewska-Makowska M, Hawryłkiewicz I, Vertun B, Zieliński J
Respiration. 1983 May-Jun;44(3):177-83. doi: 10.1159/000194546.
In 16 patients with chronic bronchitis and advanced cor pulmonale admitted to hospital due to heart failure, a controlled 6-weeks oxygen therapy, 17 h a day, was performed. The trial was started when patients were out of the exacerbation of the disease in a respiratory and circulatory steady state. Pulmonary hemodynamics, blood viscosity, packed cell volume and basic lung function data before and after oxygen therapy were compared. A significant fall of mean pulmonary arterial pressure from 42 to 30 mm Hg without a change in the cardiac output was found. Blood viscosity and packed cell volume-significantly decreased. Arterial oxygen tension did not significantly change. It seems that 17-hours per day oxygen therapy is sufficient to induce regression of anatomic changes in pulmonary arteries, a main cause of pulmonary hypertension in hypoxic cor pulmonale.
对16例因心力衰竭入院的慢性支气管炎合并晚期肺心病患者进行了为期6周的控制性氧疗，每天吸氧17小时。试验在患者处于呼吸和循环稳定状态、病情未加重时开始。比较了氧疗前后的肺血流动力学、血液粘度、红细胞压积和基础肺功能数据。结果发现平均肺动脉压从42毫米汞柱显著降至30毫米汞柱，而心输出量未发生变化。血液粘度和红细胞压积显著降低。动脉血氧张力无显著变化。每天17小时的氧疗似乎足以使肺动脉解剖学改变（缺氧性肺心病肺动脉高压的主要原因）消退。
