Maianskaia N N, Panin L E, Poliakov L M
Vopr Med Khim. 1983 Mar-Apr;29(2):73-7.
Changes in serum lipoprotein pattern and in total content of low density lipoproteins (LDL) and very low density lipoproteins (VLDL) were studied in blood and liver tissues of rats during physical exercise and restoration. Physical training induced synthesis of liver lipoproteins, in particular of their protein components. An initial period of lipoprotein synthesis in the liver tissue was preceded by transient activation of lysosomes in hepatocytes and their translocation towards nuclei. When lysosome translocation was depressed by vinblastine or colchicine injected 1 h before the physical exercise, an increase in total amount of LDL and VLDL fractions in liver and blood could not be observed. The inhibition of lysosomal proteolytic activity by hordox also impaired an increase in blood and liver lipoproteins. The data obtained suggest that activation of lysosomes and their translocation towards nuclei are important for induction of lipoprotein synthesis in liver tissue during physical exercise.
研究了大鼠在体育锻炼和恢复过程中血液和肝脏组织中血清脂蛋白模式以及低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）总含量的变化。体育锻炼诱导肝脏脂蛋白的合成，特别是其蛋白质成分的合成。在肝脏组织中脂蛋白合成的初始阶段之前，肝细胞中的溶酶体短暂激活并向细胞核移位。当在体育锻炼前1小时注射长春碱或秋水仙碱抑制溶酶体移位时，未观察到肝脏和血液中LDL和VLDL组分总量的增加。hordox对溶酶体蛋白水解活性的抑制也损害了血液和肝脏脂蛋白的增加。获得的数据表明，溶酶体的激活及其向细胞核的移位对于体育锻炼期间肝脏组织中脂蛋白合成的诱导很重要。
