Gage F H, Björklund A, Stenevi U
Brain Res. 1983 May 23;268(1):27-37. doi: 10.1016/0006-8993(83)90387-6.
The cholinergic and adrenergic afferents innervating the hippocampal formation in the rat reach the target region via three distinctly separate routes, two dorsal and one ventral one. Partial deafferentation of the hippocampus obtained by destruction of the dorsal routes (through the fimbria-fornix and the supracallosal striae) resulted in removal of 90% and 60% of the cholinergic and adrenergic innervations, respectively, within one month. By 6-10 months after lesion, the remaining cholinergic and adrenergic inputs, reaching the target via the ventral route, had expanded more than two-fold, resulting in a significant recovery in the original cholinergic and adrenergic innervation patterns. Because of its slow and protracted time-course and its ability to re-establish innervation also in initially denervated areas, this compensatory collateral sprouting phenomenon may be of particular interest for the understanding of the long-term, protracted functional recovery that is seen both after experimental brain lesions as well as in patients with severe brain injuries.
支配大鼠海马结构的胆碱能和肾上腺素能传入神经通过三条明显不同的途径到达目标区域，两条是背侧途径，一条是腹侧途径。通过破坏背侧途径（通过穹窿-海马伞和胼胝体上纹）获得的海马部分去传入神经支配，在一个月内分别导致胆碱能和肾上腺素能神经支配减少90%和60%。损伤后6至10个月，通过腹侧途径到达目标的剩余胆碱能和肾上腺素能输入增加了两倍多，导致原始胆碱能和肾上腺素能神经支配模式显著恢复。由于其缓慢且持久的时间进程以及在最初去神经支配区域重新建立神经支配的能力，这种代偿性侧支发芽现象对于理解实验性脑损伤后以及重度脑损伤患者中出现的长期、持久的功能恢复可能特别有意义。
