Bläckberg L, Hernell O
FEBS Lett. 1983 Jul 4;157(2):337-41. doi: 10.1016/0014-5793(83)80571-7.
Bile salt-stimulated lipase is a milk enzyme unique to the higher primates. Its molecular and kinetic characteristics differ greatly from other lipolytic enzymes; e.g., pancreatic lipase and lipoprotein lipase. It has a much higher app. Mr, 310000 on gel filtration and 100000 after denaturation. It requires primary bile salts for optimal activity and bile salts also protect the enzyme from proteolytic and heat inactivation. It may, due to its low substrate specificity, contribute to the utilization of a variety of milk lipids. Since it lacks positional specificity, digestion of milk triglycerides should be complete, which may explain why fat absorption is more efficient in breast-fed than in formula-fed infants.
胆汁盐刺激脂肪酶是高等灵长类动物特有的一种乳酶。其分子和动力学特性与其他脂解酶有很大不同，例如胰脂肪酶和脂蛋白脂肪酶。它的表观分子量要高得多，凝胶过滤法测得为310000，变性后为100000。它需要初级胆汁盐来达到最佳活性，胆汁盐还能保护该酶不被蛋白水解和热灭活。由于其底物特异性较低，它可能有助于多种乳脂的利用。由于它缺乏位置特异性，乳甘油三酯的消化应该是完全的，这也许可以解释为什么母乳喂养的婴儿比配方奶喂养的婴儿脂肪吸收更有效。
