Widhalm K, Zwiauer K, Weber H
Infusionsther Klin Ernahr. 1983 Apr;10(2):82-9.
8 massively obese adolescents (2 girls, 6 boys, mean age 12.6 +/- 2.1 years, mean overweight 74 +/- 14%) were treated for 3 weeks with a very low calory diet (VLCD), containing 240 kcal, 33 g protein, 25.5 g carbohydrates and 0.7 g fat. Mean weight loss after 3 weeks was 9.47 +/- 2.8 kg. The mean loss of total nitrogen was 232.4 +/- 73.2 g. Great individual variations in regard to the amounts of nitrogen loss occurred. The mean nitrogen loss over the period of 21 days was 113.3 +/- 71.2 g. Three patients reached positive nitrogen balance in the third week. No pathological changes could be shown for serum electrolytes and enzymes as well as for glucose, urea and creatinine. At the end of the first week serum uric acid values were elevated, but reached normal values at the end of the diet period. 3 patients were treated with Allopurinol 200 mg for 7 to 14 days. Serum protein concentrations fell significantly from 7.64 +/- 0.3 to 7.0 +/- 0.2 g/dl, whereas serum albumin concentrations remained constant. Cholesterol and LDL-cholesterol fell significantly (p less than 0.001) to "supranormal" values, HDL-cholesterol and triglycerides remained almost constant. 24-h-ECG investigations before, during and after the diet did not reveal any pathological findings.
8名极度肥胖青少年（2名女孩，6名男孩，平均年龄12.6±2.1岁，平均超重74±14%）采用极低热量饮食（VLCD）治疗3周，该饮食含240千卡热量、33克蛋白质、25.5克碳水化合物和0.7克脂肪。3周后平均体重减轻9.47±2.8千克。总氮平均损失232.4±73.2克。氮损失量存在很大的个体差异。21天期间的平均氮损失为113.3±71.2克。3名患者在第三周达到正氮平衡。血清电解质、酶以及葡萄糖、尿素和肌酐均未显示出病理变化。第一周结束时血清尿酸值升高，但在饮食期结束时恢复正常。3名患者接受200毫克别嘌醇治疗7至14天。血清蛋白浓度从7.64±0.3显著降至7.0±0.2克/分升，而血清白蛋白浓度保持不变。胆固醇和低密度脂蛋白胆固醇显著下降（p<0.001）至“超常”值，高密度脂蛋白胆固醇和甘油三酯几乎保持不变。饮食前、饮食期间和饮食后的24小时心电图检查未发现任何病理结果。
