Herlitz H, Ricksten S E, Lundin S, Thorén P, Aurell M, Berglund G
Ren Physiol. 1983;6(3):145-50. doi: 10.1159/000172893.
In 7-week-old male, spontaneously hypertensive rats (SHR) and matched normotensive control rats, Wistar Kyoto Rats (WKY), a bilateral renal denervation was performed. In two additional groups of rats a sham denervation was done (SHRS, WKYS). The animals were then kept in metabolic cages during a 10-day period during which sodium intake, urine volume, urinary sodium excretion, fecal sodium excretion, urinary aldosterone excretion and plasma renin activity were determined. Fractional urinary excretion of sodium was higher in the denervated SHR (p less than 0.1) and WKY (p less than 0.05) during the first 3 days after denervation, but during the following 3-day periods no difference between denervated and sham-operated groups was noted. The difference in fractional urinary excretion of sodium initially was due to a diminished urinary sodium excretion in the sham-operated groups since both SHRS and WKYS exhibited a significant increase between the first and the last 3-day period. Urine volume increased significantly in both SHR and WKY after denervation. Urinary aldosterone excretion on the 7th day after denervation was significantly lower in SHR compared to WKY, but there was no significant difference between the denervated and sham-operated groups. PRA was also significantly lower in SHR but no significant decrease was seen after denervation.
对7周龄雄性自发性高血压大鼠（SHR）和配对的正常血压对照大鼠——Wistar Kyoto大鼠（WKY）进行双侧肾去神经支配术。另外两组大鼠进行假去神经支配术（SHRS，WKYS）。然后将动物置于代谢笼中10天，在此期间测定钠摄入量、尿量、尿钠排泄、粪钠排泄、尿醛固酮排泄和血浆肾素活性。去神经支配后的最初3天，去神经支配的SHR（p<0.1）和WKY（p<0.05）的尿钠排泄分数较高，但在随后的3天期间，去神经支配组和假手术组之间未发现差异。最初尿钠排泄分数的差异是由于假手术组尿钠排泄减少，因为SHRS和WKYS在第一个和最后一个3天期间均显著增加。去神经支配后，SHR和WKY的尿量均显著增加。去神经支配后第7天，SHR的尿醛固酮排泄显著低于WKY，但去神经支配组和假手术组之间无显著差异。SHR的PRA也显著较低，但去神经支配后未见显著降低。
