Vaĭsman B L, Popov V B, Ignat'eva T V
Biull Eksp Biol Med. 1983 Jul;96(7):27-9.
It has been demonstrated that thalidomide is capable of a noticeable stabilization of the enzymes from rabbit, pig and guinea-pig liver microsomal fractions. Administration of thalidomide to guinea-pigs resulted in an increase of microsomal hydroxylase activity measured by the aniline test. The growth of the activity of microsomal enzymes led to an abrupt drop of ascorbic acid concentration in guinea-pig organs. It is suggested that thalidomide has a teratogenic action on the species which are incapable of the synthesis of ascorbic acid by making this vitamin deficiency in embryonal tissues. Probably, it is the deficiency of ascorbic acid that inhibits the synthesis of collagen in embryonal limbs and disturbs their sensory ganglia.
已证明沙利度胺能够显著稳定来自兔、猪和豚鼠肝微粒体组分的酶。给豚鼠施用沙利度胺会导致通过苯胺试验测得的微粒体羟化酶活性增加。微粒体酶活性的增长导致豚鼠器官中抗坏血酸浓度急剧下降。有人认为，沙利度胺对无法合成抗坏血酸的物种具有致畸作用，因为它会使胚胎组织中缺乏这种维生素。可能正是抗坏血酸的缺乏抑制了胚胎肢体中胶原蛋白的合成并扰乱了它们的感觉神经节。
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