Fujiwara A, Mitao M, Nagai N, Matsumoto K, Katsube Y
Nihon Sanka Fujinka Gakkai Zasshi. 1983 Jul;35(7):873-81.
As a treatment for malignant ovarian tumor, whole abdominal irradiation including the upper abdomen is more useful. Between December, 1975 and November, 1980, we additionally applied whole abdominal irradiation by the moving strip technique (1,600 rad) after operation and whole pelvic irradiation (3,000 rad) to 43 cases of malignant ovarian tumor (serous cystadenocarcinoma-24, mucinous cystadenocarcinoma-7, mesodermal mixed tumor-3, clear cell carcinoma-2, endometrioid carcinoma-2, malignant granulosa cell tumor-1, malignant Brenner tumor-1 and metastatic tumor-3). Out of 10 cases with complete resection of the tumor, nine patients are surviving without recurrence, and also some advanced cases with incomplete operation have shown a remarkable reduction in the tumor size. As to complications, diarrhea during lower abdominal irradiation as well as nausea and vomiting during upper abdominal irradiation were observed, but no characteristic changes were observed upon checking peripheral blood, liver and renal function; thus most cases completed the whole therapy without interruption. Some cases that had appeared to respond favorably course showed a rapid recurrence after 1.5-2 years, so four cases were given repeated irradiation, but results were not so satisfactory. Further study of radiation and combinations with other therapies is now being tried.
作为恶性卵巢肿瘤的一种治疗方法，包括上腹部在内的全腹照射更为有效。1975年12月至1980年11月期间，我们对43例恶性卵巢肿瘤（浆液性囊腺癌24例、黏液性囊腺癌7例、中胚叶混合瘤3例、透明细胞癌2例、子宫内膜样癌2例、恶性颗粒细胞瘤1例、恶性勃勒纳瘤1例和转移性肿瘤3例）术后采用移动条技术追加全腹照射（1600拉德）及全盆腔照射（3000拉德）。在10例肿瘤完全切除的病例中，9例患者存活且无复发，一些手术不彻底的晚期病例肿瘤大小也显著缩小。关于并发症，观察到下腹照射期间出现腹泻以及上腹照射期间出现恶心和呕吐，但检查外周血、肝肾功能时未发现特征性变化；因此大多数病例未中断地完成了整个治疗。一些起初反应良好的病例在1.5至2年后迅速复发，所以对4例患者进行了再次照射，但效果不太令人满意。目前正在尝试对放疗以及与其他疗法的联合进行进一步研究。
