Lewin E, Bleck V
Neuropharmacology. 1983 May;22(5):665-8. doi: 10.1016/0028-3908(83)90161-2.
Brain inosine and hypoxanthine were measured in mice at intervals following the intraperitoneal injection of pentylenetetrazol (PTZ), 100 mg/kg. These purines increased only after myoclonic jerks appeared and were maximal at the time of tonic hindlimb extension. Phenytoin and phenobarbital, which prevent tonic hindlimb extension, delayed the elevations of inosine and hypoxanthine. Although inosine has been found to have both epileptogenic and antiepileptic actions, the late increase in inosine found following PTZ probably has no physiological role.
在腹腔注射100mg/kg戊四氮（PTZ）后的不同时间间隔，测定了小鼠脑中的肌苷和次黄嘌呤。这些嘌呤仅在肌阵挛性抽搐出现后增加，并在强直性后肢伸展时达到最大值。苯妥英和苯巴比妥可预防强直性后肢伸展，它们延迟了肌苷和次黄嘌呤的升高。尽管已发现肌苷具有致痫和抗痫作用，但PTZ后发现的肌苷后期增加可能没有生理作用。
