应激后大鼠仰卧束缚诱导胃损伤的发展与愈合
Post-stress development and healing of supine-restraint induced stomach lesions in the rat.
作者信息
Vincent G P, Paré W P
出版信息
Physiol Behav. 1982 Oct;29(4):721-5. doi: 10.1016/0031-9384(82)90245-1.
In Experiment 1, rats were subjected to 3 hr of supine restraint and sacrificed either immediately, 30, 60, 90, 120 or 180 min following restraint. Rats sacrificed 90 min after restraint revealed significantly more stomach lesions as compared to other treatment conditions. The healing rate for supine-restraint ulcers was observed in Experiment 2 and comparisons with conventional restraint procedures, as reported in other publications, would suggest a slower healing rate for lesions induced with supine restraint. Experiment 3 indicated that cimetidine significantly accelerated the rate of healing for supine-restraint lesions.
在实验1中，大鼠接受3小时的仰卧位束缚，然后在束缚后立即、30、60、90、120或180分钟处死。与其他处理条件相比，束缚后90分钟处死的大鼠胃损伤明显更多。在实验2中观察了仰卧位束缚溃疡的愈合率，与其他出版物报道的传统束缚程序相比，仰卧位束缚诱导的损伤愈合率较慢。实验3表明，西咪替丁显著加速了仰卧位束缚损伤的愈合速度。
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