Attanasio A, Blank B, Rager K, Gupta D
Endokrinologie. 1982 Oct;80(2):129-34.
Preliminary experiments showed that a course of 3 X 5000 IU Human Chorionic Gonadotropin (HCG) every alternate day in 5 patients with Klinefelter Syndrome caused increment in the circulating levels of testosterone, estradiol, and Sex Hormone Binding Globuline (SHBG). The levels of free testosterone, however, declined in 3 subjects and recorded no change in the remaining two. Estradiol/testosterone ratio on day 0 showed high correlation (r = 0.853) with augmented SHBG. It has been postulated that higher amount of SHBG is perhaps potentiating a reduction in the bioavailability of testosterone.
初步实验表明，在5例克兰费尔特综合征患者中，每隔一天给予一个疗程（3次，每次5000国际单位）的人绒毛膜促性腺激素（HCG），可使睾酮、雌二醇和性激素结合球蛋白（SHBG）的循环水平升高。然而，3名受试者的游离睾酮水平下降，其余两名受试者的游离睾酮水平无变化。第0天的雌二醇/睾酮比值与升高的SHBG呈高度相关（r = 0.853）。据推测，较高水平的SHBG可能会增强睾酮生物利用度的降低。
