van der Sluis R F, Holland R, Yap S H
Neth J Surg. 1982 Sep;34(4):163-7.
Gastric lesions produced in pigs were used as a model to assess the efficiency and safety of Neodynium YAG laser in photocoagulation of bleeding upper gastrointestinal lesions. Bleeding gastric lesions were induced in heparinized animals and photocoagulated by a series of pulses of varying duration. Depth of necrosis in the intact gastric wall was examined as a function of radiation density and exposure time. Histologic examination was performed 1 hour and 3,7 and 21 days after exposure. The results showed that tissue destruction was less with intermittent application of energy than with a continuous radiation. intermittent administration of energy of high density (82 watts) and a short exposure time (1 sec) resulted in efficient photocoagulation, with tissue destruction not deeper than halfway through the muscularis propria. No perforation was observed in these experiments.
猪产生的胃部病变被用作模型，以评估钕钇铝石榴石激光对上消化道出血性病变进行光凝治疗的有效性和安全性。在肝素化的动物身上诱发出血性胃部病变，并通过一系列不同持续时间的脉冲进行光凝。检查完整胃壁的坏死深度与辐射密度和暴露时间的关系。在暴露后1小时、3天、7天和21天进行组织学检查。结果表明，与连续辐射相比，间歇性施加能量时组织破坏较少。间歇性给予高密度（82瓦）能量和短暴露时间（1秒）可实现有效的光凝，组织破坏不超过固有肌层的一半深度。在这些实验中未观察到穿孔现象。
