血管活性肠肽（VIP）和具有N端组氨酸及C端异亮氨酸酰胺的肽（PHI）可刺激人心肌膜中的腺苷酸环化酶活性。

Vasoactive intestinal peptide (VIP) and peptide having N-terminal histidine and C-terminal isoleucine amide (PHI) stimulate adenylate cyclase activity in human heart membranes.

作者信息

Taton G, Chatelain P, Delhaye M, Camus J C, De Neef P, Waelbroeck M, Tatemoto K, Robberecht P, Christophe J

出版信息

Peptides. 1982 Nov-Dec;3(6):897-900. doi: 10.1016/0196-9781(82)90057-2.

Abstract

The presence of receptors, recognized by Vasoactive Intestinal Peptide (VIP) and Peptide having N-terminal Histidine and C-terminal Isoleucine amide (PHI), was documented in membranes from human right auricle and left ventricular cardiac muscle by the ability of these peptides to stimulate adenylate cyclase. The capacity of VIP and PHI to activate the enzyme was comparable, in auricle as well as ventricle membranes, the affinity of the system being moderately higher for VIP than for PHI. In auricles, dose-effect curves appeared compatible with the coexistence of high-affinity and low-affinity VIP receptors. PHI could not, however, discriminate these subclasses of VIP receptors.

摘要

通过血管活性肠肽（VIP）和N端为组氨酸、C端为异亮氨酸酰胺的肽（PHI）刺激腺苷酸环化酶的能力，在人右心耳和左心室心肌膜中证实了这些肽的受体的存在。在心房和心室膜中，VIP和PHI激活该酶的能力相当，该系统对VIP的亲和力略高于对PHI的亲和力。在心房中，剂量效应曲线似乎与高亲和力和低亲和力VIP受体的共存相符。然而，PHI无法区分VIP受体的这些亚类。