• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

超氧化物歧化酶无法抑制亚铁离子和抗坏血酸介导的透明质酸解聚。

The inability of superoxide dismutase to inhibit the depolymerization of hyaluronic acid by ferrous ions and ascorbate.

作者信息

Hofmann H, Schmut O

出版信息

Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;214(3):181-5. doi: 10.1007/BF00414560.

DOI:10.1007/BF00414560
PMID:6905674
Abstract

Superoxide radicals were investigated as to their capability of depolymerizing the hyaluronic acid of the bovine vitreous body. Using viscometry it was found that O2 radicals, generated by the hypoxanthine/xanthine oxidase method or the combination of NADH and phenazine methosulphate, degraded hyaluronic acid. This reaction was suppressed by superoxide dismutase, catalase, and peroxidase. In contrast, the depolymerization of hyaluronic acid by oxidation-reduction systems like ascorbic acid or ferrous ions was abolished by catalase and peroxidase while superoxide dismutase showed no effect.

摘要

对超氧自由基使牛玻璃体透明质酸解聚的能力进行了研究。通过粘度测定法发现，由次黄嘌呤/黄嘌呤氧化酶法或烟酰胺腺嘌呤二核苷酸（NADH）与硫酸甲基吩嗪组合产生的O2自由基会降解透明质酸。超氧化物歧化酶、过氧化氢酶和过氧化物酶可抑制此反应。相比之下，过氧化氢酶和过氧化物酶可消除由氧化还原系统（如抗坏血酸或亚铁离子）引起的透明质酸解聚，而超氧化物歧化酶则无此作用。

相似文献

1
The inability of superoxide dismutase to inhibit the depolymerization of hyaluronic acid by ferrous ions and ascorbate.超氧化物歧化酶无法抑制亚铁离子和抗坏血酸介导的透明质酸解聚。
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;214(3):181-5. doi: 10.1007/BF00414560.
2
Metal ion catalyzed liquefaction of vitreous by ascorbic acid: role of radicals and radical ions.
Ophthalmic Res. 1992;24(1):1-7. doi: 10.1159/000267137.
3
Effect of metal chelators and antiinflammatory drugs on the degradation of hyaluronic acid.金属螯合剂和抗炎药物对透明质酸降解的影响。
Arthritis Rheum. 1982 Dec;25(12):1469-76. doi: 10.1002/art.1780251213.
4
[The change of hyaluronic acid of the vitreous humour by oxidation-reduction-systems (author's transl)].
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1976 Dec 31;201(2):169-74. doi: 10.1007/BF00410068.
5
[The different effects of fe(II)- and fe(III)-ions on the hyaluronic acid of the vitreous body (author's transl)].
Klin Monbl Augenheilkd. 1978 Feb;172(2):261-3.
6
[Electron microscopic investigations of vitreous collagen after treating the vitreous with liquefying substances (author's transl)].用液化物质处理玻璃体后玻璃体胶原的电子显微镜研究（作者译）
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1975 Aug 6;196(2):187-97. doi: 10.1007/BF00414805.
7
Iron ion induced haemolysis: effect of caeruloplasmin, albumin and ascorbate (vitamin C).
Int J Biochem. 1983;15(8):1067-71. doi: 10.1016/0020-711x(83)90044-7.
8
Studies on the generation of hydrogen peroxide during some non-enzymic reactions changing the hyaluronic acid molecule.关于在一些改变透明质酸分子的非酶促反应过程中过氧化氢生成的研究。
Biochim Biophys Acta. 1975 Dec 5;411(2):231-5. doi: 10.1016/0304-4165(75)90303-7.
9
Effects of superoxide dismutase and catalase on catalysis of 6-hydroxydopamine and 6-aminodopamine autoxidation by iron and ascorbate.超氧化物歧化酶和过氧化氢酶对铁和抗坏血酸催化6-羟基多巴胺和6-氨基多巴胺自氧化的影响。
Biochem Pharmacol. 1981 Aug 15;30(16):2279-85. doi: 10.1016/0006-2952(81)90099-x.
10
A kinetic study on iron stimulation of the xanthine oxidase dependent oxidation of ascorbate.铁对黄嘌呤氧化酶依赖性抗坏血酸氧化的刺激作用的动力学研究。
Biometals. 2003 Sep;16(3):435-9. doi: 10.1023/a:1022523920998.

引用本文的文献

1
The Role of Particle Inhalation in Idiopathic Pulmonary Fibrosis.颗粒物吸入在特发性肺纤维化中的作用
Int J Mol Sci. 2025 Sep 8;26(17):8736. doi: 10.3390/ijms26178736.
2
Mucus increases cell iron uptake to impact the release of pro-inflammatory mediators after particle exposure.黏液增加细胞铁摄取，从而影响颗粒暴露后促炎介质的释放。
Sci Rep. 2023 Mar 9;13(1):3925. doi: 10.1038/s41598-023-30335-2.
3
Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis.香烟烟雾颗粒诱导的肺损伤与铁稳态

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).超氧化物歧化酶。红细胞铜蛋白（血铜蛋白）的酶功能。
J Biol Chem. 1969 Nov 25;244(22):6049-55.
3
Metal catalysis in the depolymerization of hyaluronic acid by autoxidants.抗氧化剂介导的透明质酸解聚中的金属催化作用
Int J Chron Obstruct Pulmon Dis. 2022 Jan 12;17:117-140. doi: 10.2147/COPD.S337354. eCollection 2022.
4
Cigarette smoke degrades hyaluronic acid.香烟烟雾会降解透明质酸。
Lung. 1989;167(4):237-45. doi: 10.1007/BF02714952.
J Am Chem Soc. 1972 Oct 18;94(21):7570-2. doi: 10.1021/ja00776a047.
4
Depolymerization of polysaccharides through the generation of free radicals at a platinum surface: a novel procedure for the controlled production of free-radical oxidations.通过在铂表面产生自由基实现多糖解聚：一种控制自由基氧化产物生成的新方法。
Arch Biochem Biophys. 1971 Feb;142(2):615-22. doi: 10.1016/0003-9861(71)90526-1.
5
Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.超氧化物歧化酶：改进的测定方法及一种适用于丙烯酰胺凝胶的测定方法。
Anal Biochem. 1971 Nov;44(1):276-87. doi: 10.1016/0003-2697(71)90370-8.
6
Free radicals and inflammation: protection of synovial fluid by superoxide dismutase.自由基与炎症：超氧化物歧化酶对滑液的保护作用
Science. 1974 Aug 9;185(4150):529-31. doi: 10.1126/science.185.4150.529.
7
The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen.还原型硫酸吩嗪与分子氧反应中超氧阴离子的产生。
Biochem Biophys Res Commun. 1972 Jan 31;46(2):849-54. doi: 10.1016/s0006-291x(72)80218-3.
8
Studies on the generation of hydrogen peroxide during some non-enzymic reactions changing the hyaluronic acid molecule.关于在一些改变透明质酸分子的非酶促反应过程中过氧化氢生成的研究。
Biochim Biophys Acta. 1975 Dec 5;411(2):231-5. doi: 10.1016/0304-4165(75)90303-7.
9
A consideration of the effects of added solutes on the activity of bovine superoxide dismutase.添加溶质对牛超氧化物歧化酶活性影响的研究
Biochem J. 1977 Mar 1;161(3):697-9. doi: 10.1042/bj1610697.
10
Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Its role in degradation of hyaluronic acid by a superoxide-generating system.在铁盐存在下超氧化物依赖性形成羟基自由基。其在超氧化物生成系统对透明质酸降解中的作用。
FEBS Lett. 1978 Dec 15;96(2):238-42. doi: 10.1016/0014-5793(78)80409-8.