超氧化物歧化酶无法抑制亚铁离子和抗坏血酸介导的透明质酸解聚。
The inability of superoxide dismutase to inhibit the depolymerization of hyaluronic acid by ferrous ions and ascorbate.
作者信息
Hofmann H, Schmut O
出版信息
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;214(3):181-5. doi: 10.1007/BF00414560.
Superoxide radicals were investigated as to their capability of depolymerizing the hyaluronic acid of the bovine vitreous body. Using viscometry it was found that O2 radicals, generated by the hypoxanthine/xanthine oxidase method or the combination of NADH and phenazine methosulphate, degraded hyaluronic acid. This reaction was suppressed by superoxide dismutase, catalase, and peroxidase. In contrast, the depolymerization of hyaluronic acid by oxidation-reduction systems like ascorbic acid or ferrous ions was abolished by catalase and peroxidase while superoxide dismutase showed no effect.
对超氧自由基使牛玻璃体透明质酸解聚的能力进行了研究。通过粘度测定法发现，由次黄嘌呤/黄嘌呤氧化酶法或烟酰胺腺嘌呤二核苷酸（NADH）与硫酸甲基吩嗪组合产生的O2自由基会降解透明质酸。超氧化物歧化酶、过氧化氢酶和过氧化物酶可抑制此反应。相比之下，过氧化氢酶和过氧化物酶可消除由氧化还原系统（如抗坏血酸或亚铁离子）引起的透明质酸解聚，而超氧化物歧化酶则无此作用。
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