Rucki R, Ross A, Donahue J, Moros S
J Pharm Sci. 1978 Sep;67(9):1297-300. doi: 10.1002/jps.2600670928.
With increasing amounts of electroinactive amitriptyline, each of the three chlordiazepoxide reduction waves shifted to more cathodic half-wave potentials and decreased in limiting current. The shift was most pronounced up the 1:1 mole ratio but continued up to ratios of 200:1. This behavior was observed in several supporting electrolytes and was not due to change in pH since this factor was maintained constant as the amitriptyline concentration was increased. Shifts in E1/2 and reductions in limiting current may arise in several ways, such as complex formation between the two drugs or adsorption of the amitriptyline onto the surface of the dropping mercury electrode hindering chlordiazepoxide reduction. Most data point to adsorption as the cause.
随着无电活性的阿米替林量增加，三种氯氮卓还原波中的每一个都向更正的半波电位移动，并且极限电流降低。这种移动在1:1摩尔比时最为明显，但在高达200:1的比例时仍会持续。在几种支持电解质中都观察到了这种行为，并且这不是由于pH值的变化，因为当阿米替林浓度增加时该因素保持恒定。E1/2的移动和极限电流的降低可能以多种方式出现，例如两种药物之间形成复合物或阿米替林吸附到滴汞电极表面阻碍氯氮卓还原。大多数数据表明吸附是原因。
