褐家鼠线粒体DNA的核苷酸序列，包括异亮氨酸tRNA、谷氨酰胺tRNA和甲硫氨酸起始tRNA的基因。

Nucleotide sequence of Rattus norvegicus mitochondrial DNA that includes the genes for tRNAile, tRNAgln and tRNAf-met.

作者信息

Wolstenholme D R, Fauron C M, Goddard J M

出版信息

Gene. 1982 Nov;20(1):63-9. doi: 10.1016/0378-1119(82)90087-7.

Abstract

The nucleotide sequence of a segment of mtDNA from Rattus norvegicus (rat) which contains the genes for tRNAile, tRNAgln and tRNAf-met has been determined. A detailed comparison has been made between this sequence and the corresponding sequences of mouse, human and bovine mtDNAs with regard to the primary and secondary structure of the tRNA genes, the regions connecting the tRNA genes, and the regions flanking the tRNA genes which code for the carboxyl terminus of URF-1 and the amino terminus of URF-2. No differences were found in the nucleotide sequences of the genes for tRNAile, tRNAgln and tRNAf-met in mtDNAs from three different female lines of rats (SASCO-1, SASCO-2 and Wild-UT) that differ by substitutions of 0.8% to 1.8% of their total nucleotides.

摘要

已确定来自褐家鼠（大鼠）的一段线粒体DNA（mtDNA）的核苷酸序列，该序列包含异亮氨酸tRNA、谷氨酰胺tRNA和甲硫氨酸起始tRNA的基因。就tRNA基因的一级和二级结构、连接tRNA基因的区域以及编码URF-1羧基末端和URF-2氨基末端的tRNA基因侧翼区域而言，已对该序列与小鼠、人类和牛线粒体DNA的相应序列进行了详细比较。在三种不同雌性品系大鼠（SASCO-1、SASCO-2和野生UT）的线粒体DNA中，异亮氨酸tRNA、谷氨酰胺tRNA和甲硫氨酸起始tRNA基因的核苷酸序列未发现差异，这三种品系大鼠的总核苷酸有0.8%至1.8%的替换差异。