Lyle W H
J Rheumatol Suppl. 1981 Jan-Feb;7:96-9.
Penicillamine is used to treat heavy metal poisonings because it forms complexes in vitro with several toxic metals, including lead, cadmium, mercury, and gold. Urinary excretion of lead is immediately, markedly increased by penicillamine, but this is not true for the urinary excretion of cadmium, mercury, and gold. There is evidence that cadmium is shifted from 1 binding site to another in vivo; this may also be true of mercury and gold. Whether the effects of such possible shifts are beneficial or adverse is unknown.
青霉胺用于治疗重金属中毒，因为它在体外能与多种有毒金属形成络合物，包括铅、镉、汞和金。青霉胺可使尿铅排泄立即显著增加，但对镉、汞和金的尿排泄情况并非如此。有证据表明，镉在体内从一个结合位点转移到另一个结合位点；汞和金可能也是如此。这种可能的转移所产生的影响是有益还是有害尚不清楚。
