Franquin J C, Baume L J
J Biol Buccale. 1981 Jun;9(2):163-81.
In collaboration with the Research Department on vitamins and nutrition of Hoffmann-Laroche Laboratories, an experiment has been conducted, in strictly controlled dietary conditions, to study the effects of a maternal deficiency in vitamin A on the cranio-dental development of rat fetuses and of young weanling rats. A minimal dose of 6 international units per day for 100 g of body weight was required by the mothers for the gestation evolution and a natural birth. Hypovitaminosis A induced, in the fetuses, after 21 intrauterine days, a generalized delay in growth and development proportional to the deficiency severity. In the cranial base and the toothgerms, the delay reached over two fetal days. No teratogenic action was noted. The troubles observed in 21 day old fetuses seemed to disappear in young rats, 21 days after natural parturition. This compensation seemed to be related to a prolonged gestation, proportional to the vitamin deficiency and equal to the growth delay observed at the 21 fetal day. Only modifications in the molars, consisting in coronal dimension and enamel mineral density changes were still observed.
与霍夫曼-罗氏实验室的维生素与营养研究部合作，在严格控制的饮食条件下进行了一项实验，以研究母体维生素A缺乏对大鼠胎儿及幼龄断奶大鼠颅牙发育的影响。母亲维持妊娠进展及自然分娩，每天每100克体重所需的最小剂量为6国际单位。宫内21天后，胎儿维生素A缺乏症导致生长发育普遍延迟，延迟程度与缺乏严重程度成正比。在颅底和牙胚中，延迟超过两个胎儿日。未观察到致畸作用。自然分娩21天后，21日龄胎儿中观察到的问题在幼鼠中似乎消失了。这种补偿似乎与妊娠期延长有关，妊娠期延长与维生素缺乏成正比，且与胎儿21日龄时观察到的生长延迟相等。仅在磨牙中仍观察到变化，包括牙冠尺寸和釉质矿物质密度的改变。
