Krebs J B, Mir G N
Arzneimittelforschung. 1981;31(8):1251-4.
1-(2,6-Dimethylphenyl)-3-methylamidinourea hydrochloride (lidamidine hydrochloride) has previously been reported to inhibit intestinal smooth muscle contractile activity in vivo and in vitro. This study showed lidamidine also inhibited contractile activity in the isolated gravid rat uterus preparation and antagonized, the spasmogenic effects of acetylcholine, serotonin, oxytocin, and PGF2 alpha and BaCl2. Increasing Ca2+ concentrations in the bathing medium from 0.9 mmol/l to 7.2 mmol/l effectively antagonized the lidamidine inhibition of responses to BaCl2 and acetylcholine in the gravid rat uterus preparation. These results suggest that the spasmolytic effect of lidamidine may be due to its interference with the availability of Ca2+ necessary for excitation-contraction coupling in smooth muscle.
1-（2,6-二甲基苯基）-3-甲基脒基脲盐酸盐（盐酸利达脒）先前已有报道称其在体内和体外均能抑制肠道平滑肌的收缩活性。本研究表明，盐酸利达脒还能抑制离体妊娠大鼠子宫标本的收缩活性，并拮抗乙酰胆碱、5-羟色胺、催产素、前列腺素F2α和氯化钡的致痉挛作用。将浴液中的钙离子浓度从0.9毫摩尔/升提高到7.2毫摩尔/升，可有效拮抗盐酸利达脒对妊娠大鼠子宫标本中氯化钡和乙酰胆碱反应的抑制作用。这些结果表明，盐酸利达脒的解痉作用可能是由于其干扰了平滑肌兴奋-收缩偶联所需钙离子的可用性。
