Mest H J, Zehl U, Sziegoleit W, Taube C, Förster W
Prostaglandins Leukot Med. 1982 Jun;8(6):553-63.
In two groups of medical students (group A n=13, group B n=9, aged 23 to 28 years) we estimated the levels of PGE, PGF2 alpha, 6-keto-PGF1 alpha and thromboxane(TX)B2 by means of radioimmunoassay in the peripheral venous blood immediately before (BES) and 15-30 min after (AES) examination stress and compared these to control levels. Furthermore we determined the circulating platelet aggregates, the heart rate and blood pressure changes. Heart rate and systolic blood pressure increased in the BES period expressing a stressful situation. In BES the plasma level of PGE increased from 84 to 249 pg/ml (p less than 0.001), whereas PGF2 alpha was unchanged. The increase of PGE level seems to be an expression of the increased sympathetic nervous activity existing in the stressful situation. The level of 6-keto-PGF1 alpha, the stable metabolite of prostacyclin, behaved differently in the two groups. In group A there was a statistically significant increase (p less than 0.05), whereas in group B the 6-keto-PGF1 alpha level was unchanged. In AES the TXB2 level increased from 113 to 167 pg/ml (p less than 0.01), whereas under BES conditions the TXB2 level was not changed. Simultaneously with the increased TXB2 level the circulating platelet aggregates were increased. The increase in TXB2 level occurring only after the end of the examination may offer a possible explanation of the frequent appearance of heart attacks after stressful situations.
在两组医学生中（A组n = 13，B组n = 9，年龄23至28岁），我们通过放射免疫分析法测定了在考试应激前即刻（BES）和应激后15 - 30分钟（AES）外周静脉血中前列腺素E（PGE）、前列腺素F2α（PGF2α）、6 - 酮 - 前列腺素F1α（6 - keto - PGF1α）和血栓素（TX）B2的水平，并将这些水平与对照水平进行比较。此外，我们还测定了循环血小板聚集体、心率和血压变化。在BES期间，心率和收缩压升高，表明处于应激状态。在BES时，PGE的血浆水平从84 pg/ml升高至249 pg/ml（p < 0.001），而PGF2α未发生变化。PGE水平的升高似乎是应激状态下交感神经活动增强的一种表现。前列环素的稳定代谢产物6 - keto - PGF1α的水平在两组中的表现有所不同。在A组中有统计学显著升高（p < 0.05），而在B组中6 - keto - PGF1α水平未发生变化。在AES时，TXB2水平从113 pg/ml升高至167 pg/ml（p < 0.01），而在BES条件下TXB2水平未发生变化。与TXB2水平升高同时，循环血小板聚集体增加。仅在考试结束后出现的TXB2水平升高可能为应激状态后心脏病发作频繁出现提供一种可能的解释。
