Oguma S, Takatsuki K, Uchino H, Kamada N, Oguma N, Kuramoto A
Cancer. 1982 Dec 15;50(12):2928-34. doi: 10.1002/1097-0142(19821215)50:12<2928::aid-cncr2820501237>3.0.co;2-u.
The prognostic value of several clinical and hematologic features, recorded at diagnosis, in chronic phase Ph1 positive chronic myelocytic leukemia (CML), was analyzed in 135 patients using life-table analysis. About one third of patients were atomic bomb survivors and they had been examined twice a year before the diagnosis of CML. In general, features representing tumor cell burden, i.e., leukocyte count, spleen sizes, and absolute differential cell counts of all granulocyte series cells except myeloblasts affected survival significantly, while sex, age, hemoglobin, platelets and features representing quality of leukemia, i.e. neutrophils alkaline phosphatase score, percent Ph1 positive cells in bone marrow, and percent differentials of all granulocyte series cells except promyelocytes and segmented neutrophils were all insignificant. Multivariate life-table analysis was also performed using age, sex, hemoglobin, platelets, and leukocyte count as predictor variables. The result was that leukocyte was the single most important factor in this analysis and annual death rates between low risk (risk ratio less than 0.8) and high risk (risk ratio greater than 1.4) differed considerably up to four years from diagnosis, indicating our formula to calculate risk ratio is valid as a grading parameter of chronic phase Ph1 positive CML within four years from diagnosis.
运用寿命表分析法，对135例慢性期Ph1阳性慢性粒细胞白血病（CML）患者诊断时记录的若干临床和血液学特征的预后价值进行了分析。约三分之一的患者是原子弹爆炸幸存者，在诊断为CML之前他们每年接受两次检查。一般来说，代表肿瘤细胞负荷的特征，即白细胞计数、脾脏大小以及除原始粒细胞外所有粒细胞系列细胞的绝对分类细胞计数，对生存有显著影响，而性别、年龄、血红蛋白、血小板以及代表白血病质量的特征，即中性粒细胞碱性磷酸酶评分、骨髓中Ph1阳性细胞百分比以及除早幼粒细胞和分叶核中性粒细胞外所有粒细胞系列细胞的分类百分比均无显著意义。还以年龄、性别、血红蛋白、血小板和白细胞计数作为预测变量进行了多变量寿命表分析。结果表明，白细胞是该分析中唯一最重要的因素，从诊断起长达四年的时间里，低风险（风险比小于0.8）和高风险（风险比大于1.4）患者的年死亡率差异相当大，这表明我们计算风险比的公式作为诊断后四年内慢性期Ph1阳性CML的分级参数是有效的。
