出血性疾病患者中的乙型肝炎表面抗原循环免疫复合物（HBsAg-CICs）

Hepatitis B surface antigen circulating immune complexes (HBsAg-CICs) in patients with bleeding disorders.

作者信息

Anh-Tuan N, Novák E, Hollán S R

出版信息

Vox Sang. 1981 Jan;40(1):12-6. doi: 10.1111/j.1423-0410.1981.tb00663.x.

DOI:10.1111/j.1423-0410.1981.tb00663.x

Abstract

Approximately 90% of 67 multi-transfused patients with bleeding disorders were positive either for anti-HBs (85%) or HBsAg (45%). Using a polyethylene glycol trypsinization assay, we found anti-HbsAg-containing specific circulating immune complexes (HBsAg-CICs) in 3 of the 57 HBsAg-negative haemophiliacs possessing anti-HBs. The occurrence of HBsAg-CICs may be a regular event in the conversion phase of HBs infection. Circulating immune complexes as detected by the anticomplementary assay were found in 32 of the 67 (48%) patients.

摘要

在67例多次输血的出血性疾病患者中，约90%的患者抗-HBs（85%）或HBsAg（45%）呈阳性。通过聚乙二醇胰蛋白酶消化试验，我们在57例抗-HBs阳性的HBsAg阴性血友病患者中的3例中发现了含抗-HbsAg的特异性循环免疫复合物（HBsAg-CICs）。HBsAg-CICs的出现可能是HBs感染转化阶段的常见事件。在67例患者中的32例（48%）中发现了通过抗补体试验检测到的循环免疫复合物。