Morelli M, Porceddu M L, Imperato A, Di Chiara G
Brain Res. 1981 Aug 3;217(2):375-9. doi: 10.1016/0006-8993(81)90014-7.
Bilateral kainate-induced lesions of the substantia nigra prevented or dramatically reduced the catalepsy produced by haloperidol. In contrast, infusion of 1 or 4 micrograms 6-OHDA in the medial forebrain bundle, which decreased striatal DA by 30% and 80% respectively, failed to affect or actually potentiated haloperidol catalepsy. Since intranigral kainate, in contrast to 6-OHDA, destroys pars reticulata neurons it appears that these neurons are essential for the expression of haloperidol-catalepsy.
双侧红藻氨酸诱导的黑质损伤可预防或显著减轻氟哌啶醇引起的僵住症。相比之下，在前脑内侧束注入1微克或4微克6-羟基多巴胺，分别使纹状体多巴胺减少30%和80%，但未能影响氟哌啶醇引起的僵住症，实际上反而增强了该症状。由于与6-羟基多巴胺不同，黑质内注入红藻氨酸会破坏黑质网状部神经元，因此看来这些神经元对于氟哌啶醇引起的僵住症的表现至关重要。
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