衰老和蛋白质缺乏小鼠肠道黏膜的免疫成分
Immune components of the intestinal mucosae of ageing and protein deficient mice.
作者信息
Lim T S, Messiha N, Watson R R
出版信息
Immunology. 1981 Jul;43(3):401-7.
The studies were designed to investigate the effect of ageing and low protein (4%) diet on antibody-dependent cell-mediated cytotoxicity (ADCC) and IgA concentration in the intestine. Both ADCC activity and IgA concentration were shown to reach mature levels at 17 weeks old. The effect of ageing was greater on ADCC activity which showed a drastic drop in activity at 75 weeks old than IgA which had only a slight decline in concentration at this age. The low protein diet has a greater suppressive effect on IgA concentration than on ADCC activity. As the duration of feeding low protein to the young mice increased, greater decline in IgA concentration in the intestine was observed. There was, however, no significant difference from the normal mice in ADCC activity and IgA concentration of aged and adult mice given short term (8 weeks) low protein diet.
这些研究旨在调查衰老和低蛋白（4%）饮食对抗体依赖性细胞介导的细胞毒性（ADCC）以及肠道中IgA浓度的影响。ADCC活性和IgA浓度在17周龄时均达到成熟水平。衰老对ADCC活性的影响更大，ADCC活性在75周龄时急剧下降，而IgA浓度在这个年龄段仅略有下降。低蛋白饮食对IgA浓度的抑制作用比对ADCC活性的抑制作用更大。随着给幼鼠喂食低蛋白的时间延长，观察到肠道中IgA浓度下降得更多。然而，给予短期（8周）低蛋白饮食的老年和成年小鼠的ADCC活性和IgA浓度与正常小鼠没有显著差异。
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