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外周血容量感受器对行为和脑去甲肾上腺素能神经元的调控

Control of behaviour and brain noradrenaline neurons by peripheral blood volume receptors.

作者信息

Persson B, Svensson T H

出版信息

J Neural Transm. 1981;52(1-2):73-82. doi: 10.1007/BF01253099.

DOI:10.1007/BF01253099
PMID:6974763
Abstract

A moderate blood volume load or experimental hemorrhage caused in the conscious rat reciprocal alterations in locomotor activity and norepinephrine turnover in brain regions largely innervated by nucleus locus coeruleus. Other brain regions as well as other central neurotransmitters (dopamine, 5-hydroxytryptamine) investigated did not show similar reciprocal changes. These data taken together with previous electrophysiological evidence support the notion that peripheral blood volume receptors participate in the control of brain norepinephrine neurons in the locus coeruleus as well as behaviour.

摘要

在清醒大鼠中,适度的血容量负荷或实验性出血会导致在很大程度上由蓝斑核支配的脑区中运动活动和去甲肾上腺素周转率发生相互改变。所研究的其他脑区以及其他中枢神经递质(多巴胺、5-羟色胺)并未显示出类似的相互变化。这些数据与先前的电生理证据一起支持了这样一种观点,即外周血容量感受器参与了对蓝斑核中脑去甲肾上腺素能神经元以及行为的控制。

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BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.酪氨酸羟化酶抑制剂α-甲基酪氨酸对内源性去甲肾上腺素合成的阻断作用
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