Phan-Dinh-Tuy F, Durandy A, Griscelli C, Bach M A
Scand J Immunol. 1981 Aug;14(2):193-200. doi: 10.1111/j.1365-3083.1981.tb00199.x.
T-cell subsets have been analysed in 23 cases of primary immunodeficiency with monoclonal antibodies. Functional assays investigating T-cell function--proliferative response to mitogens, antigens, and allogeneic cells, cytotoxicity generated against allogeneic target cells and helper function to pokeweek mitogen-induced immunoglobulin synthesis--were performed in parallel in the same patients. The results enabled us to delineate four groups of patients. The first group consisted of patients in whom marker and function studies show concordant data, with either normal or strongly decreased T-cell number and function. The second group consisted of patients in whom various degrees of functional abnormality coexist with subnormal T-cell number and increased suppressor T-cell proportion. In the third group, we collected all patients who showed functional deficiencies without marker abnormalities. Finally, there was a small group composed of patients whose T-cell pattern was strongly suggestive of abnormal differentiation.
已用单克隆抗体对23例原发性免疫缺陷患者的T细胞亚群进行了分析。在同一批患者中同时进行了研究T细胞功能的功能测定——对丝裂原、抗原和同种异体细胞的增殖反应、对同种异体靶细胞产生的细胞毒性以及对美洲商陆丝裂原诱导的免疫球蛋白合成的辅助功能。这些结果使我们能够将患者分为四组。第一组患者的标志物和功能研究数据一致，T细胞数量和功能正常或显著降低。第二组患者存在不同程度的功能异常，同时T细胞数量低于正常水平且抑制性T细胞比例增加。在第三组中，我们收集了所有显示功能缺陷但无标志物异常的患者。最后，有一小组患者，其T细胞模式强烈提示分化异常。
