衰老大鼠离体灌注肺血管反应性的改变。

Altered vascular responsiveness in isolated perfused lungs from aging rats.

作者信息

Tucker A, Greenlees K J, Wright M L, Migally N

出版信息

Exp Lung Res. 1982 Feb;3(1):29-35. doi: 10.3109/01902148209115813.

DOI:10.3109/01902148209115813

Abstract

Systemic vascular hyporesponsiveness has been well documented in aged rats, but a similar decreased vasoreactivity of the pulmonary vasculature has not been reported. Isolated lungs from young (3-5 months) and middle-aged (12-14 months) rats were perfused with whole blood and challenged alternately with alveolar hypoxia, angiotensin II, and 5-hydroxytryptamine. Hypoxic pulmonary vasoconstriction was less in the aging rats during both 5-min and 10-min hypoxic exposures. Likewise, log-dose response curves for angiotensin II and 5-hydroxytryptamine were right-shifted in the aging rats, indicating decreased responsiveness to the vasoactive agents. Since the vascular responses to all three vasoconstrictors were lower in the older animals, a generalized pulmonary vascular hyporeactivity with advancing age is suggested.

摘要

全身血管反应性降低在老年大鼠中已有充分记录，但类似的肺血管血管反应性降低尚未见报道。用全血灌注来自年轻（3 - 5个月）和中年（12 - 14个月）大鼠的离体肺，并交替给予肺泡低氧、血管紧张素II和5 - 羟色胺进行刺激。在5分钟和10分钟的低氧暴露期间，老年大鼠的低氧性肺血管收缩作用较弱。同样，血管紧张素II和5 - 羟色胺的对数剂量反应曲线在老年大鼠中向右移动，表明对血管活性药物的反应性降低。由于老年动物对所有三种血管收缩剂的血管反应都较低，提示随着年龄增长存在全身性肺血管反应性降低。