Winchurch R A, Hilberg C, Birmingham W, Munster A M
J Reticuloendothel Soc. 1982 Jan;31(1):31-42.
The effects of bacterial lipopolysaccharides (LPS) on the growth of allografted lymphoma cells in Balb/c mice were studied. It was determined that the injection of LPS at the time of graft implantation resulted in a transient proliferation and a delay in the rejection of the graft. This effect was not attributable to any enhancement of proliferation of the lymphoma cells by LPS nor to any activity of LPS as a competing antigen or as a polyclonal activator of antibody formation. The in vitro cytotoxicity of peritoneal macrophages from LPS-treated animals against allogeneic lymphoma cells was equal to that of mice not treated with LPS. In vitro proliferation responses of splenic lymphocytes from LPS-treated animals indicated that LPS treatment produced a differential depression of Concanavalin A (Con A) responses but phytohemagglutinin (PHA)-induced responses were elevated significantly. These results suggest that the LPS-induced impairment of cell-mediated immunity involves a subset of Con A reactive T cells whose function is important in allograft rejection.
研究了细菌脂多糖（LPS）对Balb/c小鼠同种异体移植淋巴瘤细胞生长的影响。结果表明，在移植植入时注射LPS会导致移植瘤短暂增殖并延迟排斥反应。这种效应并非归因于LPS对淋巴瘤细胞增殖的任何增强作用，也不是由于LPS作为竞争抗原或抗体形成的多克隆激活剂的任何活性。LPS处理动物的腹腔巨噬细胞对同种异体淋巴瘤细胞的体外细胞毒性与未用LPS处理的小鼠相同。LPS处理动物的脾淋巴细胞的体外增殖反应表明，LPS处理导致对刀豆球蛋白A（Con A）反应的差异性抑制，但植物血凝素（PHA）诱导的反应显著升高。这些结果表明，LPS诱导的细胞介导免疫损伤涉及Con A反应性T细胞的一个亚群，其功能在同种异体移植排斥中很重要。
Zotero 插件