几种针对人类T细胞白血病抗原的新型单克隆抗体。

Several new monoclonal antibodies directed to human T-cell leukemia antigens.

作者信息

Negoro S, Seon B K

出版信息

Cancer Res. 1982 Oct;42(10):4259-62.

Abstract

Murine monoclonal hybridoma antibodies were generated efficiently by using a human leukemia antigen preparation which was isolated from the cell membranes of MOLT-4 (a T-leukemia cell line) by means of a novel system. The generated monoclonal hybridoma antibodies were screened and characterized by a radioimmunoassay using a variety of cell specimens as targets. The results showed that the antigen(s) defined by several of these monoclonal hybridoma antibodies is associated with human T-cell leukemia and further suggest that this antigen(s) is a new type of human leukemia-associated cell surface antigen.

摘要

通过一种新型系统，利用从MOLT-4（一种T淋巴细胞白血病细胞系）细胞膜中分离出的人白血病抗体制备物，高效产生了鼠单克隆杂交瘤抗体。所产生的单克隆杂交瘤抗体通过以多种细胞标本为靶标的放射免疫测定进行筛选和鉴定。结果表明，其中几种单克隆杂交瘤抗体所定义的抗原与人T细胞白血病相关，进一步提示该抗原是一种新型的人白血病相关细胞表面抗原。

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