Edén C S, Larsson P, Lomberg H
Infect Immun. 1980 Mar;27(3):804-7. doi: 10.1128/iai.27.3.804-807.1980.
The in vitro attachment of 335 Proteus mirabilis strains from various human sources to human urinary tract epithelial cells was measured. No significant difference in adhesive capacity was found between P. mirabilis strains isolated from the blood of 89 patients with bacteremia, the stools of 36 healthy subjects and 56 patients with diarrhea, and the urine of 62 adults and 92 children with bacteriuria. High mean adhesion values were observed in all groups. The P. mirabilis strains attached only to squamous cells and not to transitional epithelial cells, whereas most of the Escherichia coli strains tested attached to both cell types; strains from patients with acute pyelonephritis attached more often than those from patients with acute cystitis or asymptomatic bacteriuria. The attachment of P. mirabilis to squamous epithelial cells was high about day 15 of the menstrual cycle of the epithelial cell donor, but low at the beginning and the end of the cycle. In contrast, the attachment of E. coli to squamous and transitional epithelial cells did not vary significantly with the menstrual cycle of the cell donor. Differences in adhesion characteristics of E. coli and P. mirabilis may relate to the differences in clinical appearance of urinary tract infections produced by the two organisms.
对来自不同人类来源的335株奇异变形杆菌菌株与人尿道上皮细胞的体外黏附情况进行了测定。在从89例菌血症患者血液、36例健康受试者及56例腹泻患者粪便、62例成人及92例儿童菌尿症患者尿液中分离出的奇异变形杆菌菌株之间，未发现黏附能力存在显著差异。所有组均观察到较高的平均黏附值。奇异变形杆菌菌株仅黏附于鳞状细胞，而不黏附于移行上皮细胞，而大多数受试大肠杆菌菌株则可黏附于这两种细胞类型；急性肾盂肾炎患者的菌株比急性膀胱炎或无症状菌尿症患者的菌株更常发生黏附。奇异变形杆菌对鳞状上皮细胞的黏附在上皮细胞供体月经周期的第15天左右较高，但在周期开始和结束时较低。相比之下，大肠杆菌对鳞状和移行上皮细胞的黏附并未随细胞供体的月经周期而发生显著变化。大肠杆菌和奇异变形杆菌黏附特性的差异可能与这两种微生物引起的尿路感染临床表现差异有关。
