Bravo I R, Acevedo C G, Gallardo V
Alcohol Clin Exp Res. 1980 Jul;4(3):248-53. doi: 10.1111/j.1530-0277.1980.tb04809.x.
A single, intraportal injection of ethanol (0.01 g/kg body weight) in the pentobarbital anesthetized dog elicited an immediate rise in the hepatic resistance to both portal and hepatic blood flows. Similar effects were produced by norepinephrine and these, as well as those of ethanol, were significantly reduced by yohimbine. Increased levels of noradrenaline were found in hepatic venous effluent during the vasoconstriction period induced by ethanol. We postulate that noradrenaline liberated from sympathetic nervous endings of the liver may be involved in vascular response to ethanol.
在戊巴比妥麻醉的犬中，经门静脉单次注射乙醇（0.01克/千克体重）会立即引起肝脏对门静脉血流和肝血流的阻力升高。去甲肾上腺素也会产生类似作用，而育亨宾可显著降低乙醇和去甲肾上腺素所产生的这些作用。在乙醇诱导的血管收缩期，肝静脉流出液中的去甲肾上腺素水平升高。我们推测，从肝脏交感神经末梢释放的去甲肾上腺素可能参与了对乙醇的血管反应。
